1. (m.) fastidio situation

2. (f.) molestia - what a nuisance it's a nuisance that the iron won't work!: ¡qué fastidio que se haya estropeado la plancha!

3. (m//f.) pesado -da - my little sister is a real nuisance: mi hermana pequeña es una pesada he's been making a nuisance of himself again: ha estado dando la lata otra vez person